PPARD and neoplasm: reported that CD36 can regulate the adaptive ability of the mitochondria through the PPARβ pathway, leading to Treg adaptation in the TME with high levels of lactic acid.[100] A recent research showed that CD36 also reduces tumor‐infiltrating CD8+ T cells by mediating the process of ferroptosis.[101] Because of the its existence in many cells, using tumor‐specific carriers with CD36 inhibitor or antibody or bispecific antibodies to inhibit CD36 may be a potential anti‐tumor strategy.