MICA and neoplasm: However, they also found that the copy number of MICA and MICB, as well as the expression of metalloproteinase, increased in the TME with high B‐cell activity, which may be a mechanism by which tumor cells adapt to B‐cell‐mediated anti‐tumor immune response.[149] Therefore, understanding the role of B cells in tumorigenesis may become a novel hotspot in tumor research.