found that NRP‐1 receptors on CD8+ T cells inhibit the expression of c‐Jun/AP‐1 after binding with ligands, leading to memory T (Tmem) cell differentiation and CD8+ T cell depletion, thus ultimately reducing the number of tumor‐infiltrating CD8+ T cells.[74] Therefore, blocking NRP‐1 can increase the number of tumor‐infiltrating CD8+ T cells to provide a suitable environment for immunotherapy, such as PD‐1 blockade. This evidence concerns the gene CD8A and neoplasm.