Knocking out NRP‐1, an important T cell surface molecule, or reducing CARMA1 expression in Treg cells to destroy the CARMA1‐BCL10‐MALT1 (CBM) complex effectively promoted IFN‐γ secretion by Treg cells[110, 112] and led to an effective anti‐tumor response. This evidence concerns the gene CARD11 and neoplasm.