Sphingosine‐1‐phosphate (S1P) is a lipid molecule that regulates various physiological processes and is closely related to angiogenesis and T cell migration[96] and is associated with the occurrence of several cancers.[97] Active S1P directly inhibited the expression of FoxO1 proteins and lipolysis by activating the lipid transcription factor PPARγ, which suppresses the mitochondrial function and promotes the differentiation of center memory T (Tcm) cells to Treg cells. The gene discussed is PPARG; the disease is cancer.