PSGL‐1, a cell‐adhesion molecule on T cells, mediates selectin‐dependent leukocyte adhesion and is closely related to inflammatory reactions.[80] Recent studies have shown that it inhibits TCR and IL‐2 signals, upregulates PD‐1 expression in depleted CD8+ T cells, and inhibits the effector function of CD8+ T cells.[81] In addition, PSGL‐1 is a receptor of the important anti‐tumor target protein VISTA. The gene discussed is SELPLG; the disease is neoplasm.