CD8A and neoplasm: reported that IFN‐γ induces Treg cells to be vulnerable to the TME, thus reducing the inhibition of effector T cells and enhancing anti‐tumor response.[110] Treg cells can also inhibit the IFN‐γ secretion activity of CD8+ T cells to activate the differentiation of M2‐like macrophages and subsequently suppress the activity of effector cells in the TME.[111] Because of the anti‐tumor effects of IFN‐γ, the strategy of promoting their secretion using tumor‐infiltrating immune cells has been explored.