reported that TLR8 could reverse the inhibitory effect of Treg cells on Teff cells in the TME by inhibiting glucose uptake, glycolysis, and the mTOR‐HIF1α‐axis,[104] thereby indicating the potential of TLR8 agonists as effective anti‐tumor drugs, and some drugs based on this strategy are on their own. This evidence concerns the gene TLR8 and neoplasm.