To conclusively assess whether ALR‐driven genotoxic cell death was p53‐mediated, we crossed Alr–/– with p53–/– mice and compared the sensitivity of WT, Alr–/–, p53–/–, and Alr–/–p53–/‐ BMDMos to irradiation or doxorubicin, a genotoxic anti‐cancer agent. This evidence concerns the gene TP53 and cancer.