Multivariate analysis showed that AFP ≥20 μg/L (hazard ratio [HR] 2.307, 95% confidence interval [CI] 1.445–3.682), multiple tumor (HR 2.471, 95%CI 1.555–3.928), and MVI (HR 3.024, 95%CI 1.856–4.925) were independent risk factors for OS and AFP ≥20 μg/L (HR 1.789, 95%CI 1.208–2.649), multiple tumors (HR 1.739, 95%CI 1.148–2.633), MVI (HR 1.900, 95%CI 1.239–2.915) were independent risk factors for tumor recurrence. This evidence concerns the gene AFP and neoplasm.