Studies focused on the relationship between CH mutation and cancer showed that an increased risk of haematologic cancers is associated with the existence of CH mutations,10, 13, 14 particularly those harboured by leukaemia driver genes (e.g. DNMT3A, ASXL1, TET2, PPM1D, TP53, RAD21, STAG2, ATM, NF1, CALR, JAK2, CBL, SETD2 and MPL). Here, C4B is linked to leukemia.