To compare the prevalence of CH mutations in cancer patients and asymptomatic individuals, we counted CH mutations located in 118 genes (which appeared in the panel used to capture DNA for asymptomatic individuals) for cancer patients and found that 1698 of 11,725 (14.5%) patients carried at least one counted CH mutation, showing a similar prevalence between the two cohorts (odds ratio = 0.921; p‐value = 1 by Fisher's exact test). Here, C4B is linked to cancer.