PROK1 and cancer: Considering the association between PROK1 in plasma and primary cancer lesions, the 5-year cancer-related survival rate of the positive group for PROK1 in both plasma and primary cancer lesions was 76.2% (95% CI 56.5‐87.9) and 92.5% (95% CI 84.9‐96.4) in both the negative group (HR 1.9 [95% CI 1.21‐2.96], P = 0.003) (Fig. 5A).