HDGFL2 and Plasmodium falciparum malaria: Due to the high levels of expression of this protein, HRP2 has been found in plasma [21], saliva [22], and urine [23] of persons infected with P. falciparum. Furthermore, since treatment of falciparum malaria with ACT removes parasites from infected erythrocytes through splenic pitting and allows for recirculation of previously infected red blood cells, following the killing of erythrocytic stage parasites, HRP2 remains detectable by RDT and other HRP2-based assays for weeks following parasite treatment [8, 24, 25].