For instance, Lnc-BM is abnormally high-expressed in BC and is linked to the adverse prognosis of the patients; Lnc-BM overexpression promotes the expressions of STAT3-dependent ICAM1 and CCL2 and further activates the JAK2/STAT3 pathway, by which it promotes brain metastasis of BC cells [27]. This evidence concerns the gene ICAM1 and breast cancer.