It’s noteworthy that recent updates have also suggested the pivotal role of other genes including Connexin43 (CX43) in the heart development, myocardial function and coordination of electrically coupled cardiomyocytes activities, and in particular, the connection between myocardial ischemia-reperfusion and Cx43 has become the focus of the field [29]. The gene discussed is GJA1; the disease is myocardial ischemia.