Downregulated tumour suppressor genes included UBE2QL1 in both sublines (expression trend confirmed by RT‐qPCR in MCF‐7 sublines; Fig. 5I); and SCUBE2, PPM1L, POLD4, SERPINB9, WWOX, EMSY, CCAR2, MOB3B, PCAT19, QSOX1, SLX1A, PFDN5, AMOTL1 and HERC1 in the ZR75‐1‐sh∆40p53 subline (Fig. 5D,E, Table S2). Here, POLD4 is linked to neoplasm.