PIK3CD and infection: These findings are reminiscent of our previous analysis of the CD8 + T cell compartment in individuals with pathogenic bi-allelic inactivating variants in DOCK8 [40, 66, 67] or gain-of-function variants in PIK3CD [39] who are also susceptible to recurrent infections with herpes viruses and have an abundance of dysfunctional exhausted-type CD8+ T cells.