MYC and pancreatic adenocarcinoma: Nonetheless, our findings from analysis of the TCGA-PAAD dataset that MUC1 is associated with activation of the MYC and NOTCH signaling pathways and poor clinical outcomes hold potentially important implications in that MUC1-C could represent a potential target for the treatment of PDACs with lineage plasticity and NE dedifferentiation (Figure 6G).