DIAPH1 and Thrombocytopenia: Therefore, human mutations and gene-targeted mice deficient in the components of the actin cytoskeleton, such as non-muscle myosin heavy chain IIA (NMMHC-IIA), α-actinin, filamin A, tropomyosin 4, diaphanous-related formin 1 (DIAPH1), and tropomodulin 3, have shown thrombocytopenia due to abnormal platelet generation [8–13].