In addition, deficiency or reduction of the major platelet membrane GPIb-IX and GPIIb/IIIa also cause macrothrombocytopenia named Bernard–Soulier syndrome (BSS) and ITGA2B/ITGB3-related thrombocytopenia, respectively [27, 28]. This evidence concerns the gene ITGB3 and Macrothrombocytopenia.