Considering the potential binding activity of RBPs and mRNAs/non-coding RNAs and the vital roles of RBPs in regulating RNA fate and tumor progression, RBP IGF2BP3 that could bind with both RMRP and ZNRF3 mRNA was screened out for further investigations because of the notably high expression of IGF2BP3 in glioma. Here, ZNRF3 is linked to central nervous system cancer.