The PRIZE (program of vascular evaluation under uric acid control by xanthine oxidase inhibitor, febuxostat: multicenter, randomized controlled) study (University Hospital Medical Information Network Clinical Trial Registry UMIN000012911) was a prospective multicenter study conducted in Japanese patients with asymptomatic hyperuricemia to evaluate the inhibitory effect of febuxostat on the progression of atherosclerosis based on carotid-artery intima-media thickness assessed by ultrasonography over a 2-year follow-up period [12]. This evidence concerns the gene XDH and hyperuricemia.