We observed increased levels of the mesenchymal markers ITGA5, COL1A1 and FN1 and decreased levels of CLDN10, CDH1, TJP1 and OCLN, which are characteristic of the epithelial phenotype, in ccRCC patients versus healthy volunteers (Fig. 1A). The gene discussed is ITGA5; the disease is nonpapillary renal cell carcinoma.