MCS are known to be crucial in cell physiology where a number of MCS proteins have been linked to neurodegenerative diseases that can also affect the optic nerve, such as spastic paraplegia (protrudin, seipin, and spastin), vesicle-associated membrane protein (VAMP)-associated protein (VAP), and retinal dystrophy with leukodystrophy (Acyl-CoA-binding domain-containing protein 5 (ACBD5)) (Krols et al., 2016). The gene discussed is ACBD5; the disease is Spastic paraplegia.