In the validation cohort (n = 1395), there was a significant overall survival (OS) advantage for TET1-MUT patients compared to TET1-WT patients (hazard ratio = 0.47 [95% confidence interval, 0.25 to 0.88], P = 0.019), which, importantly, was not associated with tumour mutation burden or high microsatellite instability; nor was it attributable to the TET1-MUT prognostic impact (P > 0.05 for both non-ICI treatment cohorts). The gene discussed is TET1; the disease is neoplasm.