TET1 binds to the secreted frizzled-related protein 2 (SFRP2) promoter and catalyses its demethylation to activate SFRP2 transcription, thereby repressing the Wnt/β-catenin signalling pathway and ultimately restraining the epithelial-mesenchymal transition (EMT) in pancreatic tumours. The gene discussed is TET1; the disease is pancreatic neoplasm.