GATA6 is a known lineage specification factor amplified in adenocarcinomas of the upper gastrointestinal tract, promoting adenocarcinoma but not squamous cell carcinoma survival in the esophagus [46], and whose loss induces a shift in pancreatic cancer from adenocarcinoma to squamous metabolic phenotype [47]. This evidence concerns the gene GATA6 and familial pancreatic carcinoma.