CRLF1 and neoplasm: Cytokine Receptor Like Factor 1 (CRLF1), a member of the cytokine type I receptor family, forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. It has been reported that CRLF1 is involved in the regulation of neuronal development and tumor progression.