Cytokine Receptor Like Factor 1 (CRLF1), a member of the cytokine type I receptor family, forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. It has been reported that CRLF1 is involved in the regulation of neuronal development and tumor progression. Here, CNTFR is linked to neoplasm.