Tumor EVs from hypoxic conditions were shown to be enriched in chemokines and immunosuppressive factors, including colony stimulating factor 1 (CSF-1), chemokine ligand 2 (CCL2), and transforming growth factor beta (TGF-β), leading to macrophage chemotaxis and polarization into an M2-like phenotype [26]. Here, CSF1 is linked to neoplasm.