To our knowledge, our study being conducted at present is the first one that investigates the association between RBP‐Jκ and CXCL11 expression in colon cancer, as well as high RBP‐Jκ and CXCL11 co‐expression in relation to malignant colon cancer transformation. The gene discussed is CXCL11; the disease is malignant colon neoplasm.