Our data showed that downregulation or upregulation of RBP‐Jκ expression in colon cancer cells suppressed or promoted tumour cell migration and invasion capacities, while upregulation or downregulation of TGF‐β1 expression in TAMs reversed the downregulation or upregulation effect of RBP‐Jκ on colon cancer cells (Figure 6B, 6C). Here, TGFB1 is linked to colonic neoplasm.