Upon NLRP3 inflammasome activation, cells secrete increased amounts of pro‐inflammatory cytokines, such as IL‐1β and IL‐18,8 which subsequently accelerates the development of obesity,9 and obesity‐related conditions such as insulin resistance and cardiovascular complications,9, 10, 11 type 2 diabetes,12 and NAFLD.13, 14, 15. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.