In addition, PPFIBP2-BRAF fusion has been reported in metastatic melanoma patient [70] and PPFIBP2-RET fusion in papillary thyroid carcinoma has shown to lead to the activation of mitogen-activated protein kinase (MAPK) pathway and growth–promoting properties [71]. This evidence concerns the gene PPFIBP2 and thyroid gland papillary carcinoma.