In another risk region indexed by the AD lead SNP rs720740034, several predicted risk variants—rs2049515, rs4341787, rs549929529, and rs242557—are connected to multiple AD-risk genes—NMT1, CRHR1, SPPL2C, MAPT, and NSF (Fig. 5H and Supplementary Table S7). The gene discussed is MAPT; the disease is Alzheimer disease.