Over the past decade, GWAS revealed a large number of AD-associated genetic loci (Supplementary Fig. S1 and Supplementary Table S1), including SORL1, ABCA7, CLU, CR1, INPP5D, CD33, BIN1, PICALM, PTK2B, and APOE, a locus that has been repeatedly validated across different studies4. Here, PICALM is linked to Alzheimer disease.