AKT1 and non-small cell lung carcinoma: Thus, the identification of relatively more down-regulated genes in Cluster 2 compared with those in Cluster 3 against Cluster 1 in the RAS-PI3K-AKT signaling pathway indicates that a reduced expression level of cell cycle-associated genes may be correlated with the presence of brachyury in KRAS-mutated NSCLC cells.