Together, these findings suggest that one or more of the three DPRs (poly-GA, poly-GP, poly-GR) generated from the 75 G4C2 repeats in the C9ubi animals likely contribute to the reduced survival of these animals, thereby establishing a C. elegans model for C9orf72-mediated ALS/FTD. Here, C9orf72 is linked to frontotemporal dementia.