STK39 and pseudohypoaldosteronism type 2: Importantly, inactivating mutations of genes encoding SLC12A family members, WNK paralogs, and OSR1/SPAK underlie a wide range of inherited human diseases, including pseudohypoaldosteronism type II, Gitelman and Bartter syndromes, highlighting the importance of the WNK-OXSR1/SPAK-SLC12A pathway for normal physiology31,35–37.