To understand which p27 domain could be responsible for Palbo response in CRC, we transduced SW620 cells (low p27) with p27 WT or mutant forms, unable to interact with cyclin/CDKs (p27CK-) or with stathmin (p271-170), a cytosolic protein involved in the regulation of microtubule stability and vesicular trafficking and previously shown to interact with p27 (Fig. 2C) [20, 34, 35]. Here, CDKN1B is linked to colorectal carcinoma.