An analysis of cerebrospinal fluid (CSF) samples from 287 participants in the ADNI database over 3 to 6 years identified a 16-peptide signature that could not only differentiate between patients with AD and cognitively normal (CN) participants but could also predict progression from mild cognitive impairment (MCI) to AD better than the traditional Aβ and tau biomarkers [9]. The gene discussed is MAPT; the disease is Alzheimer disease.