Multiple other DMRs were detected: ZFP57 (identified by both comb-p and DMRcate); LMTK3 (Additional file 1: Fig. 8G) and FBXO44 (identified by comb-p only) for the rate of cognitive decline as measured by the slope of CDR-SB in patients with MCI (Additional file 2: Table 4C); LOC105375131 and GAL3ST2 (both identified by comb-p alone) for conversion status in CN participants (Additional file 2: Table 4D); and FGFR2 (identified by both comb-p and DMRcate) for conversion status in patients with MCI (Additional file 2: Table 4E). Here, LMTK3 is linked to Mental deterioration.