MAPT and Alzheimer disease: Another recent study of patients from both Japanese and North American ADNI databases, which defined disease progression based on the change in Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) scores (≥ 1, progression; < 1, stable), identified several prognostic factors in early AD: baseline tau protein levels in CSF and scores from Mini-Mental State Examination (MMSE), Functional Activities Questionnaire, and 13-item Alzheimer’s Disease Assessment Scale-cognition subscale [11].