In this study, we found several DMRs previously implicated in AD, including those annotated to HOXA4, HOXB6/HOXB9 that were associated with the rate of cognitive decline as measured by the slopes of mPACCtrailsB/mPACCdigit, and CDR-SB, respectively; and those annotated to DUSP22 and PM20D1 that were associated with conversion status in CN and MCI participants, respectively. This evidence concerns the gene HOXA4 and Mental deterioration.