For the probe annotated to GABBR1 among the top 1000 DMPs associated with MCI to AD conversion status in the AddNeuroMed study (cg06512249, β =  − 0.03, P = 0.003), the direction was consistent with multiple probes in the same region from this study (cg03316098, β =  − 0.05, P = 0.01; cg10234998, β =  − 0.10, P = 0.005; cg12061917, β =  − 0.07, P = 0.001; cg21481950, β =  − 0.06 P = 0.007) even though cg06512249 did not reach the nominally significant threshold in this study (P > 0.05) (Additional file 1: Fig. 8E). The gene discussed is GABBR1; the disease is Alzheimer disease.