More importantly, KCNQ1OT1 was reported to be overexpressed in DN, and KCNQ1OT1 downregulation limited proliferation and fibrosis and accelerated apoptosis in DN cell models [14], indicating that KCNQ1OT1 might be related to the promotion of DN development. The gene discussed is KCNQ1OT1; the disease is liver dysplastic nodule.