The levels of cytokines IL-1β, IL-6, IL-8, MCP-1, and IL-10, and of plasminogen activator inhibitor 1 (PAI-1), were reported to be increased over the acute phase and that IL-6, IL-8, MCP-1, and IL-10 formed a cytokine network in the acute phase of sepsis [15]. The gene discussed is SERPINE1; the disease is Sepsis.