As shown in Table 4, the results of univariate logistics models found that bilateral pitting edema of the hands (OR=0.074, 95%CI (0.006–0.968), P=0.047) and good response to prednisolone (OR=0.039, 95%CI (0.005–0.311), P=0.002) were negatively associated with malignancy in RS3PE, and elevation of bFGF (>10ng/ml) (OR=14.084, 95%CI (2.421–83.332), P=0.003) was positively associated with malignancy in RS3PE. Here, FGF2 is linked to cancer.