MAPT and hypertensive disorder: One of the key findings in this study was that white matter lesions and hypertension were related to both baseline and longitudinal CSF p-Tau/Aβ40 increases in the absence of abnormal Aβ pathology whereas they had no association with CSF Aβ42/Aβ40 or Aβ40 alone, suggesting vascular risk factors may be closely linked to CSF p-Tau/Aβ40 independent of Aβ pathology.