At baseline, elevated CSF p-Tau/Aβ40 was unrelated to CSF Aβ42/Aβ40 but was associated with older age (R = 0.28 [95% ci, 0.15, 0.41]), male sex (estimate = 4.2×10-5 [95% ci, 6.4×10-7, 6.8×10-5]), higher WMH (R = 0.19 [95% ci, 0.06, 0.32]), and HTN (estimate = 4.1×10-5 [95% ci, 2.9×10-5, 1.0×10-4]) but not diabetes (Fig. 1A–F). The gene discussed is MAPT; the disease is diabetes mellitus.