MAPT and hypertensive disorder: 2A, standardized β (βstd) = 0.22 [95% ci, 0.08, 0.37], p = 0.003). None of these significant risk factors (age, sex, WMH, HTN) were related to CSF Aβ42/Aβ40 or CSF Aβ40, and only age was related (R = 0.25 [95% ci, 0.11, 0.37], p < 0.001) to the non-ratio CSF p-Tau measurement (Supplemental fig. 3). In addition, older age was related to higher WMH (R = 0.29 [95% ci, 0.16, 0.42], p < 0.001) and HTN (estimate = 3.3 [95% ci, 1.2, 5.3], p = 0.001); HTN and WMH were also positively associated (estimate = 0.24 [95% ci, 0.08, 0.39], p = 0.005).