CSF p-Tau/Aβ40 (Fig. 3A, βstd = −0.29 [95% ci, −0.50, −0.09]), FDG SUVR (metaROIs) (Fig. 3B, βstd = 0.28 [95% ci, 0.07, 0.50]), and aHCV (Fig. 3C, βstd = 0.52 [95% ci, 0.33, 0.72]) all predicted subsequent cognitive decline (ΔPACC). Here, SMUG1 is linked to Mental deterioration.