CSF1R and congenital isolated hyperinsulinism: To investigate the function of BEMs after they replaced microglia, a single mild concussive Closed Head Injury (CHI) was given to mice 30 days after CSF-1R inhibitor treatment and WBRT; microglia/BEMs morphology and phagocytic activities were measured following recognition memory test by NOR (Fig. 6a).