As shown in Table 3, a logistic regression analysis showed that the miR-499a-5p expression pattern (OR = 3.28, 95% CI 1.09–9.95, P < 0.05) and BNP expression pattern (OR = 2.95, 95% CI 1.01–8.60, P < 0.05) served as independent prognostic factors for 28-day survival in patients with sepsis. The gene discussed is NPPB; the disease is Sepsis.