HMGB1 and Sepsis: For instance, miR-15a could distinguish between sepsis and systemic inflammatory response syndromes [12]; miR-103a-3p alleviates sepsis-induced liver injury by targeting HMGB1 [13]; miR-21-3p modulates sepsis-induced cardiac dysfunction by regulating SORBS2 [14]; miR-499-5p overexpression mitigates cell apoptosis in lung tissues and represses inflammation in sepsis-induced lung injury [15].