Additionally, it has been demonstrated that the downregulation of miR-132 aggravates both amyloid and tau pathology in AD model mice and that it regulates the expression of inositol 1,4,5-trisphosphate 3-kinase B (ITPKB), a regulator of BACE1 activity [25]. The gene discussed is ITPKB; the disease is Alzheimer disease.