A whole pro-tumor strategy is put in place by the immune system: decrease in Th1 cells (anti-tumor) is offset by an increase of Th2 cells (pro-tumor), cytotoxic T-cells number and function are inhibited, immunosuppressive MDSC, T-reg cells and Tfh cells increase their function, inhibitory cytokines (i.e. IL-10) and checkpoint receptors (i.e. PD-1) are upregulated and the conditions in the lymph nodes are even more immunosuppressive. This evidence concerns the gene IL10 and neoplasm.