In the present study, we hypothesized that (1) treatment with Ang-(1–7)/MasR agonists will rescue cognitive impairment and decrease VCID-induced NfL levels as compared to HF-saline treated mice, and (2) NfL levels will correlate with measures of both cognitive function and VCID-induced increases in brain cytokines. Here, ANG is linked to Cognitive impairment.