As illustrated in Fig. 2A, at 8 weeks post-MI, ejection fractions (EF) were decreased in HF-Saline and Ang-(1–7) and PNA5-treated mice compared to Control-Saline-treated mice (Control-Saline, mean 50.98,± SE 1.12 n = 17 vs HF-Saline, mean 30.99± SE 2.26, n = 9, HF-A500, mean 35.56± SE 1.60, n = 7, HF-P500, 34.54 ± SE 3.86, n = 7, HF-P50, mean, 30.57± SE 3.66, n = 10, HF-A50 36.30± SE 2.18, n = 8; respectively, p ≤ 0.0002 ANOVA, Dunnett’s post). The gene discussed is ANG; the disease is hydrops fetalis.