PGP and neoplasm: To further improve the effects of cancer treatment through increasing the accumulation of antitumor drugs at tumor sites and enhancing circulation time, multicomponent ME consisting of etoposide, coix seed oil, and ginsenoside Rh2, with a small particle size (73.1 nm), entered the blood circulation through the intestinal barrier in the form of complete NPs and inhibited P-gp, then prolonged circulation time and accumulated in the tumor site [122].