MGMT and glioblastoma: The CE.6 trial showed a similar result that patients with a methylated MGMT promoter achieved significantly prolonged survival with temozolomide (median OS, 13.5 months with radiotherapy plus temozolomide vs. 7.7 months with radiotherapy alone) and those with unmethylated MGMT promoter benefited slightly from temozolomide (median OS, 10.0 months with radiotherapy plus temozolomide vs. 7.9 months with radiotherapy alone) [10], which may suggest that short-course radiotherapy increases the efficacy of temozolomide in glioblastomas with unmethylated MGMT promoter.