CD68 and neoplasm: Concerning the difference in immune cell infiltration between the infiltration zone and tumor core, we found a tendency towards higher absolute macrophage infiltration (CD68+ as well as CD163+) for the tumor core which did not reach statistical significance on a p < 0.01 level (p = 0.017 for CD68+ and p = 0.012 for CD163+, Fig. 2B/C).