SPDEF and pancreatic neoplasm: In addition, we obtained four differentially expressed TFs (CIITA, FLI1, KLF5, SPDEF; p < 0.001, Table 2), of which two (KLF5, SPDEF) were strongly positively correlated with S100P (Table 3), suggesting that S100P could be a key IRG with an important role in pancreatic cancer.