CRX-associated LCA (LCA7) accounts for roughly 2% of all LCA cases (Hull et al., 2014; Stone, 2007) and represents an especially devastating form of the disease, likely due to incomplete formation of photoreceptor outer segments, as has been reported in an LCA7 mouse model (Tran et al., 2014). Here, CRX is linked to Leber congenital amaurosis.