The data obtained from in vitro studies on androgen-deprived PCa cells together with the data from in vivo experiments in which IL13Rα1-overexpressing PCa cells were injected into castrated mice enabled us to conclude that IL13Rα1 inhibited glycolysis to disrupt the apoptosis resistance in response to androgen deprivation. This evidence concerns the gene IL13RA1 and posterior cortical atrophy.