TUBB3 and congenital fibrosis of the extraocular muscles: Of the TUBB3 amino acid substitutions that cause CFEOM, four (Arg62Gln, Arg262Cis, Ala302Thr, Asp417Asn) are often inherited as an autosomal dominant condition, while six others (Gly71Arg, Gly98Ser, Arg262His, Arg380Cis, Glu410Lys, Asp417His) are more likely to arise de novo and be associated with more severe neurological phenotypes (Tischfield et al. 2010; Whitman et al. 2016).