We previously reported that heterozygous missense variants in TUBB3, the gene that encodes the neuron-specific beta-tubulin isotype 3 (TUBB3, MIM: 602661), cause isolated or syndromic congenital fibrosis of the extraocular muscles type 3A (CFEOM3A, MIM: 600638), with remarkable genotype/phenotype correlations (Tischfield et al. 2010; Whitman et al. 2016). Here, TUBB3 is linked to medical procedure.