To further address how sepsis may alter the composition of the CD8 T cell compartment due to differential capacity memory CD8 T cell subsets to sense signals of the ‘empty’ environment and undergo homeostatic proliferation, we utilized a murine LCMV-infection model to establish memory CD8 T cells followed by a cecal ligation and puncture (CLP; Figure 2a). The gene discussed is CD8A; the disease is infection.