Such as has_circ_0136474, which regulates IL-1β-Induced chondrocyte injury through miR-766-3p/DNMT3A Signaling Pathway; Circ-BRWD1, which contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis [27,28]. Here, IL1B is linked to osteoarthritis.