In the work presented here, we utilize two orthotopic SCC base-of-tongue tumors (FaDu and Detroit 562) and a highly expressing EGFR SCC of the skin (A431) to compare the accuracy and efficiency of FGS tumor resection using ABY-029 alone versus PAI (the latter a combination of ABY-029 with “control” IRDye 700DX carboxylate). The gene discussed is EGFR; the disease is neoplasm.