Black women younger than 50 at diagnosis had an over 50% greater risk of breast cancer-specific death across all stages of HR+/HER2− and stages II-IV HR+/HER2+ disease (data not shown for stage I HR+/HER2+ because less than 5 breast cancer deaths occurred in this group) compared to non-Hispanic White women. The gene discussed is ERBB2; the disease is breast carcinoma.