Similarly, the expression of the proinflammatory cytokine IL1B mRNA (Fig. 3e) and CXCL8 (Fig. 3f) showed a clear trend of increase with a high correlation to HIF1A mRNA levels in samples from type 2 diabetic patients living at high altitude (Fig. 3g, h). This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.